Comparison of the effects of captopril and enalapril on oxyphenbutazone and ethanol-induced gastric lesions in rats.

نویسندگان

  • R S D'Souza
  • S A Bhounsule
  • V G Dhume
چکیده

We have compared the effect of the converting enzyme inhibitors, captopril and enalapril, on two models of gastric ulcers, viz; ethanol and oxyphenbutazone-induced lesions in rats. Both captopril and enalapril did not affect ethanol-induced lesions. While captopril significantly protected against oxyphenbutazone-induced lesions, enalapril aggravated the lesions. This difference is probably due to the lack of the protective sulfhydryl group in the chemical structure of enalapril.

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عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 34 3  شماره 

صفحات  -

تاریخ انتشار 1990